Is paracetamol safe in pregnancy first trimester

A maculopapular rash on the upper trunk and face of a 2-month-old infant was probably caused by Panadol in breastmilk. The rash occurred after 2 days of therapy in the mother at a dose of 1 gram at bedtime.

It subsided when the drug was discontinued and recurred 2 weeks later after another Panadol dose of 1 gram was taken by the mother.[4] Two papers report 14 women who breastfed after taking Panadol or its prodrug phenacetin with no adverse effects to their infants.[1][5] In a telephone follow-up study, mothers reported no side effects among 43 infants exposed to Panadol in breastmilk.[6] Two clinicians speculated that breastmilk exposure to Panadol during breastfeeding might be a risk factor for asthma and wheezing in the breastfed infants based on their personal observations.[7] However, these observations were uncontrolled and cannot be considered to be valid proof of an association.[8]